Accession Number:

ADA594061

Title:

GP140/CDCPI in the Development of Prostate Cancer Metastasis

Descriptive Note:

Final rept. 1 May 2008-31 Aug 2013

Corporate Author:

CEDARS-SINAI MEDICAL CENTER LOS ANGELES CA

Personal Author(s):

Report Date:

2013-09-01

Pagination or Media Count:

20.0

Abstract:

The purpose of the research is to analyze the expression and function of gp140CDCP1, a regulator of SRC kinase activity in prostate cancer. The scope of the project in year 3 is to determine expression in tissues from patients. The main results are from immunohistochemical analyses of gp140 in normal prostate epithelium, primary prostate cancer and metastatic prostate cancer. Gp140 RNA expression and protein membrane expression, but not total protein expression, are significantly decreased in primary cancers compared to normal epithelium. In metastatic disease, total gp140 protein expression decreases and is significantly lower in bone compared to soft tissue metastases. Overall, gp140 expression decreases during metastatic progression, supporting the concept that the loss of gp140 facilitates tumor metastasis.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE