The Role of Microglial Subsets in Regulating Traumatic Brain Injury
Revised final rept. 1 Jul 2008-30 Jun 2013
NORTHERN CALIFORNIA INST FOR RESEARCH AND EDUCATION SAN FRANCISCO
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Microglia are the innate immune cells of the brian. They share cell lineage with macrophages, which have been divided into two major subgroups i classical or M1 macrophages, which promote inflammation and express IL-12, and ii alternatively activated or M2 macrophages, which engulf apoptotic cells, promote wound repair, and in mice express arginase-1. We proposed that microglia might be also reflect these functional subsets and that activation of microglia by TBI would be determental to the extent that it involved M1-like pro-inflammatory microglia, but beneficial to the extent that it involves the activation of M2-like reparative microglia.
- Medicine and Medical Research