Accession Number:

ADA593730

Title:

The Role of Microglial Subsets in Regulating Traumatic Brain Injury

Descriptive Note:

Revised final rept. 1 Jul 2008-30 Jun 2013

Corporate Author:

NORTHERN CALIFORNIA INST FOR RESEARCH AND EDUCATION SAN FRANCISCO

Personal Author(s):

• Seaman, William E.

Report Date:

2013-07-01

Pagination or Media Count:

29.0

Abstract:

Microglia are the innate immune cells of the brian. They share cell lineage with macrophages, which have been divided into two major subgroups i classical or M1 macrophages, which promote inflammation and express IL-12, and ii alternatively activated or M2 macrophages, which engulf apoptotic cells, promote wound repair, and in mice express arginase-1. We proposed that microglia might be also reflect these functional subsets and that activation of microglia by TBI would be determental to the extent that it involved M1-like pro-inflammatory microglia, but beneficial to the extent that it involves the activation of M2-like reparative microglia.

Descriptors:

• *MACROPHAGES
• *TRAUMATIC BRAIN INJURIES
• ACTIVATION
• BRAIN
• CELLS(BIOLOGY)
• IMMUNITY
• INFLAMMATION
• MEDICAL RESEARCH
• TRAUMA
• WOUNDS AND INJURIES

Subject Categories:

• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE