Accession Number:

ADA592942

Title:

Development of a Novel Synthetic Drug for Osteoporosis and Fracture Healing

Descriptive Note:

Annual rept. 22 Aug 2012-21 Aug 2013

Corporate Author:

INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS

Personal Author(s):

Report Date:

2013-09-01

Pagination or Media Count:

87.0

Abstract:

This is a progress report year 2 for the development of a novel therapeutic drug salubrinal for skeletal diseases, focusing on potential treatment of osteoporosis and bone fracture. The study in the second year using animal models and in vitro cell cultures strongly supported salubrinal s action on prevention of bone loss. In animal experiments, we employed three procedures to induce bone loss. They were ovariectomy, hindlimb suspension, and administration of glucocorticoid prednisolone. In all three models, salubrinal was able to suppress reduction of bone mineral density. In those experiments, salubrinal was administered via subcutaneous injection as well as oral gavage. In in vitro experiments, salubrinal reduced the development of bone-resorbing osteoclasts and promoted the development of boneforming osteoblasts. A provisional patent was submitted for salubrinal s administration for treatment of bone diseases, and the peer-reviewed articles as well as conference abstract were published. In the third year, we will start evaluating the effects of salubrinal on the healing of bone fracture as well as the regulatory mechanism of salubrinal s action.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE