Minocycline and N-acetylcysteine: A Synergistic Drug Combination to Treat Traumatic Brain Injury
Annual rept. 30 Sep 2012-29 Sep 2013
STATE UNIV OF NEW YORK DOWNSTATE MEDICAL CENTER BROOKLYN
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Due to the changing nature of war, there is a pressing need for new treatments for traumatic brain injury TBI. The grantee previously found screened that the combination of minocycline MINO and N-acetyl cysteine NAC synergistically improved brain function when dosed one hour following closed cortical impact CCI in rats. The overall objective of this proposal is that MINONAC synergistically improves brain function following TBI. Three tasks will be done to achieve this objective 1 Differing doses of MINONAC will be tested for the ability to improve behavior and histology following closed head injury in mice CHI. 2 MINONAC was effective when dosed one hour after injury. Longer intervals between injury and drug dosing will be tested. 3 A restoration of cognitive function will be tested three months after CHI. The grantee has shown that MINO plus NAC improves cognition in two models of TBI, a single impact closed head injury CHI in mice and the CCI model in rats. The drug combination improves cognition and limits white matter injury in two models and two species. These data attest to the potency of the drug combination.
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