Accession Number:

ADA592673

Title:

Evaluation of the Human/Extreme Environment Interaction: Implications for Enhancing Operational Performance and Recovery

Descriptive Note:

Annual rept. 1 Oct 2011-30 Sep 2012

Corporate Author:

MONTANA UNIV MISSOULA

Personal Author(s):

Report Date:

2012-10-01

Pagination or Media Count:

36.0

Abstract:

The purpose of this research determines how hypoxia interacts with exercise and recovery to yield various metabolic responses that may affect performance and performance at high-altitude critical to mission success. Participants n10 completed two exercise trials under normoxic conditions 975 m that included a 90-minute interval protocol cycling. Subjects then recovered for 4 hours under the same normoxic conditions or at a high, simulated altitude of 5000 m. Muscle biopsies from the vastus lateralis were obtained before exercise, after exercise and 6 hours after exercise for the measurement of metabolic gene expression and muscle glycogen. Muscle glycogen decreased with exercise and increased with recovery with no difference between trials. The majority of the metabolic genes were suppressed after altitude exposure. These data demonstrate that high altitude exposure during recovery from exercise inhibits gene expression associated with mitochondrial development without affecting the recovery of muscle fuels.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE