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Evaluation of the Human/Extreme Environment Interaction: Implications for Enhancing Operational Performance and Recovery

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Annual rept. 1 Oct 2010-30 Sep 2011

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The purpose of this research determines how hypoxia interacts with exercise and recovery to yield various metabolic responses that may affect performance and performance at high-altitude critical to mission success. Participants completed two maximal exercise tests under hypoxia, 3000 m and normoxic, 975 m conditions. Three experimental trials were then completed hypoxia, 3000m at 60 of their hypoxic peak power HH normoxia, 975m at 60 of their hypoxic peak power NH and normoxia at 60 of their normoxic peak power NN using a randomized, counterbalanced cross-over design over the span of 3 weeks, with a minimum of 7 days between trials. Our initial findings demonstrate that exercise during hypoxia 3000 m and normoxia 975 m results in similar responses glycolytic, metabolic, and mitochondrial morphology genes, and oxidative stress markers when the exercise intensity is clamped relative to the specific environment as a of either hypoxic or normoxic peak power. There were subtle differences in the glycogen response to exerciserecovery, which is likely a function of the higher absolute workrate during the NN trial. These results demonstrate similar response patterns across the three trials and suggest the need for a more aggressive degree of hypoxia to establish differences in the metabolic gene and oxidative stress marker responses.

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  • Anatomy and Physiology
  • Medicine and Medical Research

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