Assessment of Cerebral Blood Flow Autoregulation (CBF AR) with Rheoencephalography (REG): Studies in Animals
WALTER REED ARMY INST OF RESEARCH SILVER SPRING MD
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The ability of cerebral vasculature to regulate cerebral blood flow CBF in the face of changes in arterial blood pressure SAP or intracranial pressure ICP is an important guard against secondary ischemia in acute brain injuries, and official guidelines recommend that therapeutic decisions be guided by continuous monitoring of CBF autoregulation AR. The common method for CBF AR monitoring, which rests on real-time derivation of the correlation coefficient PRx between slow oscillations in SAP and ICP is, however, rarely used in clinical practice because it requires invasive ICP measurements. This study investigated whether the correlation coefficient between SAP and the pulsatile component of the non-invasive transcranial bioimpedance signal rheoencephalography, REG could be used to assess the state and lower limit of CBF AR. The results from pigs and rhesus macaques affirm the utility of REG however, additional animal and clinical studies are warranted to assess selectivity of automatic REG-based evaluation of CBF AR.
- Anatomy and Physiology
- Medicine and Medical Research