Accession Number:

ADA592174

Title:

Global Characterization of Protein-Altering Mutations in Prostate Cancer

Descriptive Note:

Final rept. 15 Jul 2010-14 Jul 2013

Corporate Author:

WASHINGTON UNIV SEATTLE

Personal Author(s):

Report Date:

2013-08-01

Pagination or Media Count:

18.0

Abstract:

The research supported by this award aims to use a new generation of technologies for DNA sequencing to comprehensively scan the genomes of a series of prostate cancers for small mutations that disrupt protein-coding sequences. Our specific aims are as follows 1 To carry out the genome-wide identification of nonsynonymous mutations in limited number of prostate metastases using second-generation technologies for targeted capture and sequencing 2 To evaluate the mutational histories of individual mutations within the progression of the cancer in which it was observed, and to assess the prevalence of candidate cancer genes observed here in prostate cancer. 3 To perform integrative analyses of somatic mutation with gene expression and copy number change data collected on the same samples.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE