The Role of NF1 in Memory Retrieval
Annual rept. 15 Jun 2012-14 Jun 2013
COLD SPRING HARBOR LAB NY
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We have reported that NF1 affects both immediate memory and long-term memory LTM, but through different mechanisms in Drosophila Ho et al., 2007. The goal of this proposal is of studying the hypothesis as to that in long-term memory LTM, NF1 is specifically involved in mediating memory retrieval, but not required for induction and consolidation. For this purpose, three specific aims are proposed, including 1 to determine NF1 s role in memory retrieval 2 to identify ligands that activate NF1 for memory retrieval and 3 to locate the brain region at which NF1-dependent memory retrieval occurs.
- Anatomy and Physiology
- Medicine and Medical Research