Accession Number:

ADA591973

Title:

The Role of NF1 in Memory Retrieval

Descriptive Note:

Annual rept. 15 Jun 2012-14 Jun 2013

Corporate Author:

COLD SPRING HARBOR LAB NY

Personal Author(s):

Report Date:

2013-07-01

Pagination or Media Count:

6.0

Abstract:

We have reported that NF1 affects both immediate memory and long-term memory LTM, but through different mechanisms in Drosophila Ho et al., 2007. The goal of this proposal is of studying the hypothesis as to that in long-term memory LTM, NF1 is specifically involved in mediating memory retrieval, but not required for induction and consolidation. For this purpose, three specific aims are proposed, including 1 to determine NF1 s role in memory retrieval 2 to identify ligands that activate NF1 for memory retrieval and 3 to locate the brain region at which NF1-dependent memory retrieval occurs.

Subject Categories:

  • Psychology
  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE