Theory-Driven Models for Correcting Fight or Flight Imbalance in Gulf War Illness
Final rept. 1 Sep 2010-31 Aug 2013
ALBERTA UNIV EDMONTON
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The objective of this study is to create a comprehensive engineering model of endocrine-immune interaction dynamics in order to identify i theoretical failure modes of the HPA-immune axis that align with GWI, and ii promising treatment strategies that exploit the regulatory dynamics of these systems to reset control of the HPA-immune axis to normal. We are currently transferring operations and this award to Nova Southeastern University, FL, to facilitate interactions with U.S. sponsors and collaborators. Dr. Craddock, now assistant professor at Nova, will continue in his role on this project. Work has focused on the refinement of the HPA-HPG-immune multi-axis model, its validation scheme and inclusion of Th17 and neurotranmission NPY, acetylcholine, etc in the detailed immune model. Importantly we have developed an advanced prototype of a neuroinflammation model. Deployment to large-scale distributed computing platform has also advanced significantly.
- Anatomy and Physiology
- Medicine and Medical Research