Accession Number:

ADA591969

Title:

A Clinically Realistic Large Animal Model of Intra-Articular Fracture

Descriptive Note:

Annual rept. 15 Sep 2012-14 Sep 2013

Corporate Author:

IOWA UNIV IOWA CITY

Personal Author(s):

Report Date:

2013-10-01

Pagination or Media Count:

40.0

Abstract:

The primary objective of this project is to develop a novel large animal survival model of intra-articular fracture IAF in which all major pathophysiological attributes corresponding to human injuries are realistically replicated, and in which post-traumatic osteoarthritis PTOA predictably develops. Building upon the work and protocols developed during the first two project years, substantial progress was made during this third project year PY3, to establish the natural history of intra-articular fracture in the porcine model. All long-term survival experiments were completed, and the healing response, animal activity data, and inflammation history data have been analyzed. The fracture and repair protocol results in well-healed joints which the animal begins to load normally 2-4 weeks after surgical insult, and the inflammatory response is similar to that seen in injured human joints. During the upcoming PY4, the final histological analysis of these long-term experiments will be conducted, and the short-term survival study investigating the effects of therapeutic treatment which was initiated during PY3 will be completed.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE