Accession Number:

ADA591526

Title:

Integrated Immunotherapy for Breast Cancer

Descriptive Note:

Annual rept. 1 Sep 2012-31 Aug 2013

Corporate Author:

CITY OF HOPE NATIONAL MEDICAL CENTER DUARTE CA

Personal Author(s):

Report Date:

2013-09-01

Pagination or Media Count:

35.0

Abstract:

Over the first 12 months of this award, we have focused on developing an in-depth understanding of the immune system in the setting of the tumor microenvironment. We have made progress in developing methods to better analyze the relationships between primary tumor and metastatic growths with their surrounding microenvironments, and implications for immune response and dendritic cell function in vitro using 3D microculture techniques. We have further investigated the roles of specific cytokines on immune signaling and tested alternative methods for tumor eradication using combinatorial drugs in attempts to restoreenhance the immune response. Additionally, we have begun preparing breast cancer cell lines to aid quantifying progress in upcoming in vivo studies using mouse models. We anticipate that the progress made in the first 12 months will lead to combining observations into in vitro and in vivo models to better test our combinatorial immunotherapeutic strategies, restore dendritic cell function in cancer, and identifying novel tumor-associated stroma targets.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE