Mutation of Breast Cancer Cell Genomic DNA by APOBEC3B
Annual summary 1 Sep 2012-31 Aug 2013
MINNESOTA UNIV MINNEAPOLIS
Pagination or Media Count:
Over the course of my tenure on this training grant, I have discovered that an endogenous enzyme, APOBEC3B, is upregulated in the majority of breast cancers. This holds true for both primary cancer tissues as well as cell lines. I have mechanistically characterized the enzyme s activity, sub-cellular localization, preferred sequence substrate and kinetics, and impact on the cancer cell genome. In addition, I have expanded my research to include all of the available cancer types represented in the publicly accessible portion of The Cancer Genome Atlas TCGA. Using the massive data repository, I have found that the same mutational phenomenon that I have identified in breast cancer is also at work in 5 other types of cancer head neck cancer, cervical cancer, bladder cancer, squamous cell lung cancer and lung adenocarcinomas.
- Anatomy and Physiology
- Medicine and Medical Research