On the Origin of Prostate Cancer Stem Cells through Transmissible ER Stress-Mediated Epithelial to Mesenchymal Transition
Final rept. 14 Apr 2012-30 Sep 2013
CALIFORNIA UNIV SAN DIEGO LA JOLLA MOORES CANCER CENTER
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This DoD Innovation grant was based on the hypothesis that transmissible ER stress TERS promotes the Epithelial to Mesenchymal Transition EMT in differentiated prostate cancer cells, programming cancer towards a different phenotype and greater invasive characteristics. The hypothesis predicted a new and potentially important mechanism in tumorigenesis. Through the work performed during the last year, we have been able to demonstrate a link between prostate tumor ER stress, EMT, and enhanced invasiveness. The study is not finished yet but we can confidently say that the premises of the original hypothesis have been experimentally validated.
- Genetic Engineering and Molecular Biology
- Anatomy and Physiology
- Medicine and Medical Research