Accession Number:

ADA591316

Title:

Thiourea-Catalyzed Aminolysis of N-acyl Homoserine Lactones

Descriptive Note:

Journal article

Corporate Author:

ARMY RESEARCH LAB RESEARCH TRIANGLE PARK NC ARMY RESEARCH OFFICE

Report Date:

2013-01-01

Pagination or Media Count:

6.0

Abstract:

Thiourea catalysts accelerate aminolysis of N-acyl homoserine lactones AHLs, molecules integral to bacterial quorum sensing. The catalysts afford rate enhancement of up to 10 times the control in CD3CN. Mild catalysis in other polar aprotic solvents is still observed, while the activity is attenuated in polar protic solvents.

Subject Categories:

  • Biochemistry
  • Medicine and Medical Research
  • Organic Chemistry
  • Physical Chemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE