Thiourea-Catalyzed Aminolysis of N-acyl Homoserine Lactones
ARMY RESEARCH LAB RESEARCH TRIANGLE PARK NC ARMY RESEARCH OFFICE
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Thiourea catalysts accelerate aminolysis of N-acyl homoserine lactones AHLs, molecules integral to bacterial quorum sensing. The catalysts afford rate enhancement of up to 10 times the control in CD3CN. Mild catalysis in other polar aprotic solvents is still observed, while the activity is attenuated in polar protic solvents.
- Medicine and Medical Research
- Organic Chemistry
- Physical Chemistry