Cyanide Antidotes for Mass Casualties: Comparison of Intramuscular Injector by Autoinjector, Intraosseous Injection, and Inhalational Delivery
Annual rept. 26 Sep 2012-25 Sep 2013
CALIFORNIA UNIV SAN DIEGO LA JOLLA
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Current antidotes for cyanide poisoning must be administered by intravenous injection, which would not be practical for treating mass casualties as could occur in a major industrial accident or a terrorist attack. Thus, a need exists for alternative modes of administering cyanide antidotes, and we are comparing three different administration modes intramuscular injection via an autoinjector, intraosseous injection, and inhalational delivery. We have found that all three modes can rescue animals from exposure to lethal cyanide doses, and now need to determine which administration mode would be the most practical for treating a large number of cyanide-poisoned persons.