SNF5 Mutation Leads to Intractable Pain in Schwannomatosis Patients
Final rept. 15 Jun 2011-14 Jun 2013
OREGON HEALTH AND SCIENCE UNIV PORTLAND
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Ablation of snf5, in vivo, results in an increase in the number and type of sensory neurons that express the capsaicin receptor, TRPV1. Using a culture system, we have determined that soluble factor is released by snf5-- Schwann cells that acts on sensory neurons to induce the expression of TRPV1. This factor is greater than 10K molecular weight and does not affect neuron survival. The increase in the immunoreactivity of TRPV1 is correlated with an increase in the expression of functional capsaicin-sensitive ion fluxes.
- Anatomy and Physiology
- Medicine and Medical Research