Targeted Silver Nanoparticles for Dual-Energy Breast X-Ray Imaging
Final rept. 1 Mar 2011-28 Feb 2013
PENNSYLVANIA UNIV PHILADELPHIA
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We proposed to develop a silver Ag nanoparticle NP contrast agent optimized for dualenergy DE contrast-enhanced CE breast x-ray imaging. CE digital breast imaging provides an accurate method for decomposition of images into distinct breast tissue and contrast agent signals. At present, DE-CE breast imaging is performed with an iodinated contrast agent better suited for temporal subtraction CE imaging. We postulated that AgNP would be a superior contrast agent for DE-CE breast x-ray imaging. Ag filters can be used in the low-energy image acquisition to obtain a spectrum weighted just below the k-edge of Ag 25.5 keV. A low-energy spectrum optimized for Ag would also provide a superior anatomical image. We have demonstrated in proof-of-principle, the applicability of AgNP as contrast agents for use in DE-CE digital breast tomosynthesis and digital mammography. Three objectives have been met 1 Synthesize and functionalize AgNP that are monodisperse in shape, size and distribution 2 Perform vascular-enhancement, biodistribution and toxicity studies on mice and 3 develop optimal x-ray imaging techniques.
- Anatomy and Physiology
- Medicine and Medical Research
- Medical Facilities, Equipment and Supplies