Role and Mechanism of Structural Variation in Progression of Breast Cancer
Annual summary 1 Sep 2012-31 Aug 2013
VIRGINIA UNIV CHARLOTTESVILLE
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Cancer is a disease of the genome. Tumor cells progressively accumulate genomic mutations during the progression of the disease. Some of these are causative mutations that could be responsible for tumorigenesis and metastasis whereas others just reflect the increased genomic instability in tumor cells. Identifying such driver mutations and the mechanisms by which they evolve remains one of the most important questions in cancer biology. In this study we plan to utilize next generation sequencing paired with computational methods to investigate various aspects of breast cancer progression.
- Medicine and Medical Research