Endophenotypes of Dementia Associated with Traumatic Brain Injury in Retired Military Personnel
Annual rept. 30 Sep 2012-29 Sep 2013
NORTHERN CALIFORNIA INST FOR RESEARCH AND EDUCATION SAN FRANCISCO
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The goal of the project is to define the clinical phenotype of late life dementia in veterans who have been exposed to TBI. Our hypothesis is that TBI in early to mid life is associated with a dementia phenotype that has features distinguishable from AD. In the first year, we completed the screening survey portion of the study and found that over half of the veterans surveyed n289 had a history of head injury, with over 20 requiring hospitalization. Compared to those without TBI, those with TBI had higher levels of depression 61.3 for hospitalization group vs. 55.3 for head injury symptom group vs. 24.2 for non TBI group, P0.001 and PTSD 37.1 for hospitalization group vs. 21.4 head injury symptoms group vs. 8.1 for non TBI group, P0.001. We also found that TBI is associated with a higher history of psychiatric disorders and current cognitive symptoms. A manuscript based on these results is in preparation. Data is currently being collected for the crosssectional study phase of the project. The results will determine if a clinical phenotype of dementia in individuals with TBI exists, which has relevance for future treatment.
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