Accession Number:

ADA591047

Title:

Sealing Penetrating Eye Injuries With Photoactivated Bonding

Descriptive Note:

Final addendum rept. 1 Sep 2012-31 Aug 2013

Corporate Author:

MASSACHUSETTS GENERAL HOSPITAL BOSTON

Personal Author(s):

Report Date:

2013-09-01

Pagination or Media Count:

30.0

Abstract:

To develop a light-activated technology with the potential to decrease vision loss and ocular complications in warfighters sustaining penetrating eye injuries. To establish, in ex vitro and in vivo animal models, the treatment parameters for sealing corneal and scleral penetrating wounds and to close lacerations in thin eyelid-like skin. To design and evaluate a prototype light delivery device. We established that bonding amniotic membrane over penetrating cornea and scleral wounds produced immediate, water-tight seals that withstood an intraocular pressure of 350 mm Hg. We closed lacerations in eyelid-like skin with the dye light treatment, which showed less inflammation than after sutured closure. A prototype light delivery system was designed, constructed and tested to deliver retina-safe light levels while providing light levels sufficient for sealing amniotic membrane over corneal wounds. Studies demonstrated that thermal damage to the iris is not a concern during these repair treatments.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE