Accession Number:

ADA589916

Title:

Neural and Behavioral Sequelae of Blast-Related Traumatic Brain Injury

Descriptive Note:

Revised final rept. 1 Sep 2008-31 Aug 2012

Corporate Author:

CLEVELAND CLINIC FOUNDATION OH

Personal Author(s):

Report Date:

2012-11-01

Pagination or Media Count:

57.0

Abstract:

Traumatic brain injuries TBI are a common occurrence from roadside blasts of improvised explosive devices IEDs. In this cross-sectional study, we applied neurobehavioral testing and advanced MRI techniques task-activated functional MRI fMRI and diffusion tensor imaging DTI to gain a comprehensive understanding of the neural changes underlying blast-related mild TBI MTBI. We accomplished this goal by conducting advanced neuroimaging task-activated fMRI and DTI fiber tracking and neurobehavioral testing computerized assessment and standard neuropsychological testing on 60 chronic trauma patients 15 military MTBI patients who had blast injuries, 15 civilian MTBI patients with mechanical closed head injuries, 15 military and 15 civilian patients with orthopedic injuries. Key findings on the stop signal fMRI task include a distinct pattern of brain activation in the military blast MTBI group which differed from the civilian MTBI group on failed inhibition trials. On the Sternberg working memory task, fMRI findings show that increases in brain activation with memory load are reduced in specific brain regions of the military blast MTBI group, also suggesting that the chronic effects of blast MTBI differ from mechanical MTBI in civilians. We completed recruitment of subjects, scoring and entering of outcome data, and continue imaging data analysis.

Subject Categories:

  • Medicine and Medical Research
  • Ammunition and Explosives

Distribution Statement:

APPROVED FOR PUBLIC RELEASE