Accession Number:

ADA589590

Title:

Mechanisms of Mitochondrial Dysfunction in Autism

Descriptive Note:

Annual rept. 1 Jul 2012-30 Jun 2013

Corporate Author:

GEORGIA STATE UNIV ATLANTA RESEARCH FOUNDATION INC

Report Date:

2013-07-01

Pagination or Media Count:

14.0

Abstract:

The purpose of this study is to define correlations between indices of brain dysfunction, such as functional MRI fMRI and the neuropsychological testing abnormalities, with oxidative phosphorylation OXPHOS defects in children with autism spectrum disorders ASD. This study is an essential step in identifying such a phenotypic subtype, being able to perform large-scale epidemiological studies using more widely available measures, and ultimately being able to implement clinical trials for new pharmaceutical agents emerging for treatment of the OXPHOS defects which could significantly improve the functioning of children with ASD with this defect. Data acquisition is ongoing and larger numbers of subjects are needed before meaningful conclusions can be drawn from the study.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE