Mechanisms of Mitochondrial Dysfunction in Autism
Annual rept. 1 Jul 2012-30 Jun 2013
GEORGIA STATE UNIV ATLANTA RESEARCH FOUNDATION INC
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The purpose of this study is to define correlations between indices of brain dysfunction, such as functional MRI fMRI and the neuropsychological testing abnormalities, with oxidative phosphorylation OXPHOS defects in children with autism spectrum disorders ASD. This study is an essential step in identifying such a phenotypic subtype, being able to perform large-scale epidemiological studies using more widely available measures, and ultimately being able to implement clinical trials for new pharmaceutical agents emerging for treatment of the OXPHOS defects which could significantly improve the functioning of children with ASD with this defect. Data acquisition is ongoing and larger numbers of subjects are needed before meaningful conclusions can be drawn from the study.
- Anatomy and Physiology
- Medicine and Medical Research