Accession Number:

ADA589529

Title:

The Cytoplasm Translocation of the Androgen Receptor Cofactor p44 as a Target for Prostate Cancer Treatment

Descriptive Note:

Annual rept. 10 Sep 2012-9 Sep 2013

Corporate Author:

M D ANDERSON CANCER CENTER HOUSTON TX

Personal Author(s):

Report Date:

2013-10-01

Pagination or Media Count:

7.0

Abstract:

We determined the dosage reimen for adiministration of identified chemical compounds and found that identified compounds inhibited androgen-dependent growth of prostate tumors in nude mice. The growth inhibition is associated with suppression of p44 cytoplasm tranportation. We also found that the nuclear exclusion signal NES1 of p44 does not function in the differentiated prostate epithelial cells. This finding reveals a novel mechanism by which p44 subcellular tranlocation is determined and regulated during prostate development and prostate tumorigenesis.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE