Alterations of the Bone Marrow Microenvironment Contribute to Prostate Cancer Skeletal Metastasis
Annual summary 15 Apr 2011-14 Apr 2012
MICHIGAN UNIV ANN ARBOR
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The purpose of this postdoctoral training grant was to provide the PI with opportunity to explore the metastatic bone microenvironment under the supervision of the mentor, Dr. Laurie McCauley, at the University of Michigan. The research plan of this proposal was to test a hypothesis that alternations of bone marrow microenvironment contribute to metastatic prostate cancer growth in bone. The specific aims were designed to investigate the contribution of hematopoietic cellular compartment in the bone marrow to the development of prostate cancer skeletal metastasis. This study demonstrated that alternations induced by cyclophosphamide, one of the mowt widely used chemotherapeutic drugs, enhanced bone metastasis in a prostate cancer animal model. Furthermore, this study showed tha the pro-metastatic effects of cyclophosphamide were significantly reversed by suppression of CCl2, which suggests the causal role of bone marrow myeloid lineage cell expansion in promoting metastasis in the mouse model used in this study.
- Anatomy and Physiology
- Medicine and Medical Research