Targeted Nanoparticles for Kidney Cancer Therapy
Annual rept. 15 Sep 2012-14 Sep 2013
CONNECTICUT UNIV HEALTH CENTER FARMINGTON
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The objective of this proposal is to test targeted carbon nanomaterials for their ability to thermally ablate kidney cancer. Carbon nanotubes CNTs and other forms of carbon nanomaterials, such as graphene, are efficient transducers of near-infrared radiation NIR. We have shown that carbon nanotubes are effective in laser-induced thermal therapy of kidney cancer in mouse models. Our goal is to improve the anti-tumor efficacy of CNTs by targeting them uPAR, a surface receptor overexpressed in kidney cancers. We will use D5, a peptide designed in the laboratory, as the targeting ligand. In the past year, we made progress in evaluating materials for delivery of D5 and also performed microfluidic studies that will be important in optimizing delivery of our particles to tumors. We published two papers. In the upcoming year we hope to complete our conjugation studies, pursue microfluidic studies to evaluate particle characteristics that will enhance delivery, and perform in vivo efficacy studies. This grant is a mentorpredoctoral award that also focuses on training of a predoctoral candidate. The predoctoral fellow carried out the microfluidic experiments described in this progress report and presented his work at the annual Society of Rheology meeting.
- Medicine and Medical Research