Accession Number:

ADA588979

Title:

An Implantable Neuroprosthetic Device to Normalize Bladder Function after SCI

Descriptive Note:

Annual rept. 22 Sep 2012-21 Sep 2013

Corporate Author:

PITTSBURGH UNIV PA

Personal Author(s):

Report Date:

2013-10-01

Pagination or Media Count:

36.0

Abstract:

The long-term goal of our project is to develop a novel neuroprosthetic device to restore the functions of the urinary bladder for SCI people without further damaging the nervous system. Advanced technologies in electrical and computer engineering will be applied to design the novel neuroprosthetic device. Based on our previous studies, we propose in this project to use pudendal nerve stimulation and blockade to restore both continence and micturition after SCI. Our strategy does not require sacral posterior root rhizotomy, preserves the spinal reflex functions of the bowel and sexual organs, and more importantly provides the opportunity for SCI people to benefit from any advance in neural regeneration and repair techniques in the future. During the last year, we have identified problems of our implantable stimulator in awake chronic SCI animals, improved the stimulator design, and tested its functionality in anesthetized animals. These results have laid the foundation for us to further test this implantable stimulator in chronic SCI animals.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE