P11, a Biomarker for Memory Retrieval: A Possible Role in Traumatic Stress
Annual rept. 15 Sep 2012-14 Sep 2013
HENRY M JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE ROCKVILLE MD
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This year, we finally got our p11 knockout mice and were able to conduct the behavioral experiments Specific Aim 1-3. Here, we will present two sets of new results first, a control data set that included data from control mice second, an experimental data set that included data from experimental mice, which received pharmacological treatment e.g., mice received corticosterone injection and foot shock exposure. We found the latency to find platform of knockout mice was shorter than that of non-p11 knockout wild type mice during the first three training days, although both of their latencies were the same on the final day of training and probe test. This data indicate that p11 knockout in the mice might enhanced learning. We also found that corticosterone resulted in significant decreases in the time in quadrant and number of island crossing in both p11 knockout and wild type control, suggesting that corticosterone induced impairment of memory retrieval, which independent the p11 expression. The ongoing final experiments will allow us to accomplish all of our proposed aims to understand the possible molecular mechanism of p11 in memory retrieval, a molecule associated with PTSD, a devastating disorder, especially in military service members.
- Anatomy and Physiology
- Medicine and Medical Research