P11, a Biomarker for Memory Retrieval: A Possible Role in Traumatic Stress
Revised annual rept. 15 Sep 2008-14 Sep 2009
HENRY M JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE ROCKVILLE MD
Pagination or Media Count:
This is our annual repot for the project P11, A Biomarker for Memory Retrieval. A Possible Role in Traumatic Stress. We carried out all of the experiments based on the proposed research design. We tested memory retrieval performance with wild type mice, since p11 knock-out mice were not bred. We found that both footshock and glucocorticoid treatment affect memory retrieval of mice. Mice had impaired performance in the water-maze spatial task after being given footschock for 30 min. In addition, systemic corticosterone was administered to non-stressed mice 30 min before retention testing induced retention impairment. We found that stress results in increases of p11 expression in the wild type mouse brain. Therefore, the experimental procedures were tested and validated in the wild type mice and the role of p11 in memory retrieval will be further determined with p11 knockout mice in our ongoing experiments.
- Medicine and Medical Research