Metal Ion-Catalyzed Alcoholysis as a Strategy for the High Loading Destruction of Chemical Warfare Organophosphorus Agents
Final rept. Aug 2009-Nov 2010
ARMY EDGEWOOD CHEMICAL BIOLOGICAL CENTER APG MD RESEARCH AND TECHNOLOGY DIR
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Metal-catalyzed alcoholysis has proven to be an effective strategy for the rapid transformation of neutral reactive organophosphate esters of the phosphate, phosphonate, phosphorothioate, and phosphonothioate classes. This chemistry, using Laexpn 3 OMeMethanol as catalystsolvent, applied to the V and G classes of chemical warfare agents, demonstrated extremely rapid transformation to low toxicity esters with load factors of 30 for non-fluoride-releasing agents. Variation of the alcohol solvent is tolerated. Variations of the metal catalyst provide potential redress to the fluoride inhibition of the G agent class. These observations indicate that formulations based on mixed alcohol solvents combined with optimized metal catalysts for use in field decontamination, civilian security, and infrastructure scenarios provide a pathway for tuning the reaction media while retaining extremely rapid destruction kinetics.
- Organic Chemistry
- Chemical, Biological and Radiological Warfare