Accession Number:

ADA587633

Title:

Metal Ion-Catalyzed Alcoholysis as a Strategy for the High Loading Destruction of Chemical Warfare Organophosphorus Agents

Descriptive Note:

Final rept. Aug 2009-Nov 2010

Corporate Author:

ARMY EDGEWOOD CHEMICAL BIOLOGICAL CENTER APG MD RESEARCH AND TECHNOLOGY DIR

Report Date:

2013-11-01

Pagination or Media Count:

54.0

Abstract:

Metal-catalyzed alcoholysis has proven to be an effective strategy for the rapid transformation of neutral reactive organophosphate esters of the phosphate, phosphonate, phosphorothioate, and phosphonothioate classes. This chemistry, using Laexpn 3 OMeMethanol as catalystsolvent, applied to the V and G classes of chemical warfare agents, demonstrated extremely rapid transformation to low toxicity esters with load factors of 30 for non-fluoride-releasing agents. Variation of the alcohol solvent is tolerated. Variations of the metal catalyst provide potential redress to the fluoride inhibition of the G agent class. These observations indicate that formulations based on mixed alcohol solvents combined with optimized metal catalysts for use in field decontamination, civilian security, and infrastructure scenarios provide a pathway for tuning the reaction media while retaining extremely rapid destruction kinetics.

Subject Categories:

  • Organic Chemistry
  • Chemical, Biological and Radiological Warfare

Distribution Statement:

APPROVED FOR PUBLIC RELEASE