A Functional Genomic Analysis of NF1-Associated Learning Disabilities
Revised final rept. 1 Feb 2004-31 Jul 2008
CALIFORNIA UNIV IRVINE
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Learning disabilities severely deteriorate the life of many NF1 children by limiting their academic achievement, higher education and career choice. However, the pathogenic process for NF1-associated learning disabilities has not been fully understood and an effective therapy is not available. This study was proposed to identify genes that are dysregulated in the hippocampus of the Nf1- mouse model by DNA microarray analysis. Characterization of these NF1-affected genes will dramatically improve our understanding of the molecular pathogenesis underlying NF1-associated learning deficits.
- Medicine and Medical Research