The Integrative Studies of Genetic and Environmental Factors in Systemic Sclerosis
Final rept. 9 Apr 2007-8 Apr 2011
TEXAS UNIV HEALTH SCIENCE CENTER AT HOUSTON
Pagination or Media Count:
This project aims to study interactions between genetic and environmental factors in a viable system - human fibroblasts. Fibroblasts obtained from scleroderma SSc patients have a profibrotic nature that suggests a possibility of a dysregulation of biological function in the cells. On the other hand, SSc occurs in genetically susceptible individuals. A SSc susceptible genetic background may be more vulnerable to environmental triggers, such as silica a potential SSc trigger. Studies of biological functions of fibroblasts with and without SSc susceptible backgrounds in response to potential environmental triggers will provide a great opportunity to understand etiopathogenesis of SSc.
- Anatomy and Physiology
- Medicine and Medical Research