Accession Number:

ADA586835

Title:

Modified of an Accepted Animal Model of Osteomyelitis to Simulate and Evaluate Treatment of War Extremity Wounds. Addendum

Descriptive Note:

Final rept. 1 Jul 2011-30 Jun 2012, Addendum

Corporate Author:

OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS

Personal Author(s):

Report Date:

2012-07-01

Pagination or Media Count:

164.0

Abstract:

The primary goal of this project is to evaluate the efficacy of selected antibiotic regimens in an established osteomyelitis animal model of infection from MRSA, Acinetobacter baumannii, Pseudomonas aeruginosa, and Klebsiella pneumoniae. A related arm of the project at the University of Maryland-Baltimore will identify microbial gene products of the four species mentioned above with upregulated production in biofilms using two-dimensional 2D gel electrophoresis. In addition, the PI has worked with military collaborators to publish a series of peer-reviewed manuscripts outlining guidelines for prevention and management of infections.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE