ICBP90 Regulation of DNA Methylation, Histone Ubiquitination, and Tumor Suppressor Gene Expression in Breast Cancer Cells
Revised annual summary 1 Jul 2010-30 Jun 2013
CORNELL UNIV ITHACA NY
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In mammals and other higher eukaryotes, SRA-RING proteins are essential for global maintenance of DNA methylation. This research project focuses on the discovery of new ubiquitination targets for the Arabidopsis SRA-RING protein VIM1 and the human SRA-RING protein UHRF1. Additionally, it will closely examine the methylcytosine-binding specificity of UHRF1, with a specific focus on non-CpG contexts. The proposed work is ongoing, and so far the major accomplishments include creation of relevant plant lines, development of in vitro assays, and profiling of mRNA expression in null mutants.
- Medicine and Medical Research