Comprehensive Clinical Phenotyping and Genetic Mapping for the Discovery of Autism Susceptibility Genes
Special rept. Sep 2009-Dec 2012
NATIONWIDE CHILDREN'S HOSPITAL COLUMBUS OH RESEARCH INST
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Autism is an extremely common and heterogeneous neurodevelopmental disorder. While genetic factors are known to play a critical role in the etiologies of autism, the underlying genes and mechanisms remain unknown in approximately 70-75 of cases. Advances in technology and our understanding of the causes of autism are occurring at a rapid pace, affecting standards for clinical patient care. The purpose of the central Ohio registry for autism CORA is to develop a comprehensive autism registry for genetic and other studies for military and civilian families in central Ohio. Congressionally-supported funding for the project was secured, beginning in late 2009 total 2.77 million, September 30, 2009-December 31, 2012. The specific aims of the project are to support 1 development of the CORA registry 2 expansion of diagnostic and treatment services for WPAFB families through a collaboration with Dayton Childrens Medical Center DCMC 3 molecular studies to identify novel autism susceptibility genes and 4 cost and satisfaction analyses for the military services components in Aim 2.
- Genetic Engineering and Molecular Biology
- Medicine and Medical Research