New Methods of Low-Field Magnetic Resonance Imaging for Application to Traumatic Brain Injury
Annual rept. 10 Jan 2012-9 Jan 2013
HARVARD UNIV CAMBRIDGE MA
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We are developing robust low-magnetic-field implementations of MRI LFI focused on brain imaging with two complimentary test scanner systems electromagnet and permanent magnet based. We are also developing injury-sensitive MRI based on the detection of free radicals associated with injury using the Overhauser effect and subsequently imaging that modified nuclear polarization using low-field MRI OMRI. Much of the hardware development of the human head LFI test bed systems and the OMRI system is now complete. We now focused on imaging sequence development and optimization, image reconstruction, and the implementation of parallel imaging acceleration. We have successfully demonstrated high-speed free-radical OMRI, and investigated the sensitivity of spectroscopy- and image-based measurements to free radical concentrations as a path toward in vivo applications. Application of the suite of techniques and technologies from our work could advise future development of a deployable device with a high diagnostic impact, transforming diagnosis and monitoring of secondary injury prevalent in TBI.
- Anatomy and Physiology
- Medicine and Medical Research