Accession Number:

ADA585644

Title:

Use of Bioresorbable Hydrogels and Genetic Engineering to Accomplish Rapid Stabilization and Healing in Segmental Long Bone Defects

Descriptive Note:

Final rept. 15 Dec 2010-13 Feb 2012

Corporate Author:

BAYLOR COLL OF MEDICINE HOUSTON TX

Report Date:

2013-04-29

Pagination or Media Count:

65.0

Abstract:

The Fracture Putty project was initiated to develop better, faster and more efficient methods to treat difficult fractures. This contract supported study of hydrogel polymers, which are polymerized under direct control of the operating surgeon, and are also designed for biologic cleavage by osteoclast specific proteases. Processes in bone growth and repair were studied in cell cultures, mice, rats, sheep, pigs, and feasibility of lymphatic imaging was demonstrated in humans. We believe this system is safe and efficacious and will lead to profound enhancements in patient care.

Subject Categories:

  • Genetic Engineering and Molecular Biology
  • Anatomy and Physiology
  • Physical Chemistry
  • Mechanics

Distribution Statement:

APPROVED FOR PUBLIC RELEASE