Accession Number:

ADA585392

Title:

Nanomedicine for Early Disease Detection and Treatment

Descriptive Note:

Final rept. 15 Aug 2011-14 Aug 2013

Corporate Author:

METHODIST HOSPITAL HOUSTON TX

Personal Author(s):

Report Date:

2013-09-01

Pagination or Media Count:

51.0

Abstract:

A platform technology to prepare enzyme sensitive nanomedicine ESNM, which integrates the imaging and treatment capability, has been developed to report and cure diseases. ESNM is prepared with multiple layers of polyelectrolytes, sequentially assembled on an inert gold nanoparticle, using alternating charged polymers. Potentially the release kinetics could be controlled by varying polyelectrolytes with different properties, such as length, ionic strength and bond stability. Upon incubation with cells, the assembled ESNMs are taken up efficiently. The tight packing and layered assembly of the quenched polyelectrolytes slow subsequent intracellular degradation, and

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE