Damage Avoidance and Repair Mechanisms of Extreme Halophiles to Ionizing Radiation
Final rept. Apr 2010-Apr 2013
JOHNS HOPKINS UNIV BALTIMORE MD
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We investigated the molecular basis for ionizing radiation IR resistance in extremophiles using the halophilic archaeon Halobacterium salinarum as a model system and several thermophilic bacteria and archaea also highly resistant to IR. Oxidative damages are the main lesions from IR and result from the production of reactive oxygen species ROS via radiolysis of water.
- Radioactivity, Radioactive Wastes and Fission Products
- Atomic and Molecular Physics and Spectroscopy