Characterizing and Targeting Replication Stress Response Defects in Breast Cancer
Annual rept. 15 Jul 2012-14 Jul 2013
M D ANDERSON CANCER CENTER HOUSTON TX
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During the third year of this project, we have made significant progress in several of our proposed tasks. We found that TUSC4 is a potent tumor suppressor gene in breast cancer with an important function in stabilizing BRCA1 protein. In addition, we identified and validated AXL and Jag1 as two novel RSR-defect-specific membrane proteins and have successfully conjugated the antibodies against these two molecules to hollow gold nanoparticles. We also demonstrated the specific binding of these nanoparticles to RSR-defect breast cells in vitro and in vivo. Finally, we have identified and in vitro validated 5 top compound candidates that preferentially killed RSR-defect breast cells.
- Medicine and Medical Research