Accession Number:

ADA585104

Title:

Characterizing and Targeting Replication Stress Response Defects in Breast Cancer

Descriptive Note:

Annual rept. 15 Jul 2012-14 Jul 2013

Corporate Author:

M D ANDERSON CANCER CENTER HOUSTON TX

Report Date:

2013-08-01

Pagination or Media Count:

13.0

Abstract:

During the third year of this project, we have made significant progress in several of our proposed tasks. We found that TUSC4 is a potent tumor suppressor gene in breast cancer with an important function in stabilizing BRCA1 protein. In addition, we identified and validated AXL and Jag1 as two novel RSR-defect-specific membrane proteins and have successfully conjugated the antibodies against these two molecules to hollow gold nanoparticles. We also demonstrated the specific binding of these nanoparticles to RSR-defect breast cells in vitro and in vivo. Finally, we have identified and in vitro validated 5 top compound candidates that preferentially killed RSR-defect breast cells.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE