Predictors of Treatment Response to Fluoxetine in PTSD Following a Recent History of War Zone Stress Exposure
Final rept. 1 Jul 2007-30 Jun 2013
TEMPVA RESEARCH GROUP INC TEMPLE TX
Pagination or Media Count:
Although selective serotonin reuptake inhibitors SSRIs are routinely prescribed for acute stress disorder and early PTSD and recommended in the VA-DoD best practice guidelines, the efficacy of SSRIs as an early intervention for PTSD in service members returning from war-zone duty has still not been determined. Consequently, this study was designed to conduct a controlled trial of fluoxetine as an early intervention for recently redeployed soldiers, as well as to develop methodologies for understanding the multiple factors that may predict outcome. The study was conducted at two sites Carl R. Darnall Army Medical Center and Central Texas Veterans Health Care System. Despite recruitment efforts, only 42 participants were enrolled. Of these, 18 were randomized. The limited enrollment obscures interpretation of the results. No unexpected side effects were observed. Our data does not support or refute the use of SSRIs for treatment of PTSD.
- Medicine and Medical Research