Accession Number:

ADA583639

Title:

Development of Advanced Technologies for Complete Genomic and Proteomic Characterization of Quantized Human Tumor Cells

Descriptive Note:

Annual rept. 15 Jun 2012-14 Jun 2013

Corporate Author:

SWEDISH HEALTH SERVICES SEATTLE WA

Personal Author(s):

Report Date:

2013-07-01

Pagination or Media Count:

11.0

Abstract:

This research proposal will provide important insights into cancer mechanisms and blood biomarkers to assess progression and stratification of human glioblastoma. We have collected several tumor specimens to date and have made excellent progress in establishing primary tumor cell cultures from individual tissue samples. These parental cell lines have successfully been used for the generation of quantized tumor cell populations for general molecular characterization, and for evaluating the effectiveness of drug candidates in targeting these cell populations. This program will significantly advance genomic, proteomic and single-cell technologies, which will be generally applicable to all cancer-based studies

Subject Categories:

  • Biochemistry
  • Genetic Engineering and Molecular Biology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE