Production of a Novel OX40 Ligand for Clinical Use
Annual rept. 30 Sep 2011-29 Sep 2012
PROVIDENCE PORTLAND MEDICAL CENTER OR
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Cancer cells have evolved to evade immune-mediated destruction through several documented mechanisms. Our group has developed a technique to enhance immune function in tumor-bearing hosts by targeting a protein on the surface of white blood cells, termed OX40. This type of immune modulation leads to therapeutic benefit in tumor-bearing mice. We have produced a protein that binds to the human OX40 protein and activates human white blood cells. We have a cell line that produces high quantities of this protein and our goal is to test this protein for safety and efficacy in non-human primates so that we can obtain FDA approval for clinical trials in cancer patients. The long-range goal of this proposal is translate these findings to prostate cancer patients.
- Anatomy and Physiology
- Medicine and Medical Research