Fatty Acid Synthesis and Control of Caspase 2 in Prostate Cancer
Final rept. 1 Jul 2011-30 Jun 2012
DUKE UNIV DURHAM NC SCHOOL OF MEDICINE
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Although prostate cancers are initially responsive to androgen deprivation therapy, castration resistant prostate cancer demands alternative treatment options. It has been reported that the apoptotic protease, caspase 2 C2 is critical for prostate cancer cell death in several settings. Several reports have also indicated that fatty acid synthesis is critical for maintaining prostate cancer cell viability and that inhibition of fatty acid synthesis can lead to apoptosis. Finally, C2 is suppressed by high intracellular NADPH and this is not due to the redox effects of NADPH, suggesting that the synthetic role of NADPH e.g., in fatty acid synthesis may account for its ability to suppress apoptosis. Our new data suggest that manipulating metabolism, particularly inhibiting fatty acid synthesis, can alter chemosensitivity in prostate cancer cells.
- Medicine and Medical Research