Accession Number:

ADA583204

Title:

Metabolite Concentrations in the Anterior Cingulate Cortex Predict High Neuropathic Pain Impact After Spinal Cord Injury

Descriptive Note:

Journal article

Corporate Author:

VETERANS ADMINISTRATION MEDICAL CENTER MIAMI FL

Report Date:

2013-02-01

Pagination or Media Count:

23.0

Abstract:

Persistent pain is a common reason for reduced quality of life after a spinal cord injury SCI. Biomarkers of neuropathic pain may facilitate translational research and the understanding of underlying mechanisms. Research suggests that pain and affective distress are anatomically and functionally integrated in the anterior cingulate cortex and can modulate sensory and affective aspects of pain. We hypothesized that severe neuropathic pain with a significant psychosocial impact would be associated with metabolite concentrations obtained by magnetic resonance spectroscopy in the anterior cingulate cortex, indicating neuronal andor glial dysfunction. Participants with SCI and severe, high-impact neuropathic pain SCI-HPI n 16, SCI and moderate, low-impact neuropathic pain SCI-LPI n 24, SCI without neuropathic pain SCInoNP n 14, and able-bodied, pain-free control subjects A-B n 22 underwent a 3-T magnetic resonance imaging brain scan. Analyses revealed that the SCI-HPI group had significantly higher levels of myoinositol Ins P .000, creatine P .007, and choline P . 014, and significantly lower levels of N-acetyl aspartateIns P .024 and glutamate-glutamine GlxIns P .003 ratios than the SCI-LPI group. The lower GlxIns ratio significantly discriminated between SCI-HPI and the A-B P .006 and SCI-noNP P .026 groups, displayed excellent test-retest reliability, and was significantly related to greater pain severity, interference, and affective distress. This suggests that the combination of lower glutamatergic metabolism and proliferation of glia and glial activation are underlying mechanisms contributing to the maintenance of severe neuropathic pain with significant psychosocial impact in chronic

Subject Categories:

  • Biochemistry
  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE