Accession Number:

ADA583192

Title:

Molecular Mechanisms Underlying Genomic Instability in Brca-Deficient Cells

Descriptive Note:

Annual rept. 1 Mar 2012-28 Feb 2013

Corporate Author:

GENEVA FOUNDATION LAKEWOOD WA

Personal Author(s):

Report Date:

2013-03-01

Pagination or Media Count:

56.0

Abstract:

Our proposal is to explore the novel notion that it may be possible to restore near normal HR activity in Brca1 cells and tissues. We believe that this phenomenon will lead to targeted therapies to reduce lifetime risk of tumor formation in BRCA1 and potentially BRCA2 carriers.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE