Vaccines for Hantaviruses: Progress and Issues
ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD
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The Hantavirus genus of the family Bunyaviridae comprises more than 20 viruses, including several human pathogens. Hantaviruses are maintained in rodent reservoirs and are usually transmitted to humans in aerosols of rodent excreta. Oldworld rodents carry viruses that cause hemorrhagic fever with renal syndrome HFRS and new-world rodents carry viruses that cause hantavirus pulmonary syndrome HPS. Four hantaviruses cause most cases of HFRS in Asia and Europe Hantaan HTNV, Seoul SEOV, Puumala PUUV and Dobrava DOBV viruses. HPS- and HPS-causing hantaviruses were discovered in 1993 when an outbreak of severe respiratory distress of unknown etiology occurred in the USA. Most HPS cases result from infections with Sin Nombre virus in North America or Andes virus in South America 1,2.
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