Accession Number:

ADA583166

Title:

The Prenatal Development Effects of Carbon Dioxide (CO2) Exposure in Rats (Rattus Norvegicus)

Descriptive Note:

Technical rept. Dec 2011-Oct 2012

Corporate Author:

NAVAL MEDICAL RESEARCH UNIT-DAYTON WRIGHT-PATTERSON AFB OH

Report Date:

2012-10-12

Pagination or Media Count:

35.0

Abstract:

Female rats were exposed to clean air or 1.5, 2.0, 2.5, or 3.0 carbon dioxide CO2 gas for 23 hrday from GD6-20 of pregnancy. There were no remarkable post-exposure findings in adults, including no differences in bodyweight or food consumption. There were no remarkable post-exposure findings in fetal bodyweight, and no malformations or developmental variations following CO2 exposure. There were two statistically significant findings in the 3.0 CO2 group a higher mean post-implantation loss per litter early resorptions and a corresponding lower mean proportion of viable fetuses per litter. These results yield a No Observed Adverse Effect Level NOAEL of 2.5 and a Lowest Observed Adverse Effect Level LOAEL of 3.0 for CO2. Using the 2.5 NOAEL as a point of departure for a developing a CEL and an interspecies uncertainty factor of 3 yields a recommended CEL of 0.8 for CO2. Developmental endpoints are assumed to result from a single day of exposure during gestation therefore, the 24-hour EEL is also recommended to be made 0.8 CO2. These recommendations should not outweigh any other studies that may derive a lower recommendation based on relevant data and endpoints.

Subject Categories:

  • Biology
  • Toxicology
  • Inorganic Chemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE