Accession Number:

ADA582943

Title:

Repair of Nerve Cell Membrane Damage by Calcium-Dependent, Membrane-Binding Proteins (Revised)

Descriptive Note:

Annual rept. 1 Sep 2011-31 Aug 2012

Corporate Author:

VIRGINIA UNIV CHARLOTTESVILLE

Personal Author(s):

• Creutz, Carl E.

Report Date:

2012-09-01

Pagination or Media Count:

20.0

Abstract:

In the second year of this contract calcium-dependent, membrane-binding proteins of the annexin class were found to be effective at preventing damage and repairing damage to membranes caused by osmotic shock or other chemical and physical stresses using an in vitro assay involving synthetic membrane vesicles. These proteins may therefore be promising agents for protecting or promoting the repair of cell membranes in the case of spinal cord injury.

Descriptors:

• *CALCIUM
• *NERVE CELLS
• *PROTEINS
• CHOLINES
• DAMAGE
• GLYCEROLS
• LEAKAGE(FLUID)
• LIPOSOMES
• MEMBRANES
• OSMOTIC PRESSURE
• PEPTIDES
• PERMEABILITY
• REPAIR
• SPINAL CORD
• WOUNDS AND INJURIES

Subject Categories:

• Biochemistry
• Anatomy and Physiology
• Inorganic Chemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE