Accession Number:

ADA582936

Title:

Assessment of Geographical Variation in the Respiratory Toxicity of Desert Dust Particles

Descriptive Note:

Journal article

Corporate Author:

NAVAL RESEARCH LAB WASHINGTON DC CENTER FOR BIOMOLECULAR SCIENCE AND ENGINEERING

Personal Author(s):

• Taylor, Karen
• Foster, Melanie L.
• Law, J. M.
• Centeno, Jose A.
• Fornero, Elisa
• Henderson, M. S.
• Trager, Sabrina A.
• Stockelman, Michael G.
• Dorman, David C.

Report Date:

2013-01-01

Pagination or Media Count:

13.0

Abstract:

The health consequences of sand particle inhalation are incompletely understood. This project evaluated the respiratory toxicity of sand particles collected at military bases near Fort Irwin USA, in Iraq Camp Victory, Taji and Talil, and Khost Afghanistan. Our primary focus was on assessing the role of soluble metals in the respiratory toxicity of the sand particles using in vitro and in vivo methods. Replicating rat type II alveolar cell cultures RLE-6TN were exposed to sand extracts or vehicle control in serum-free media for 24 h. Cytotoxicity was determined using the 3-4,5-dimethylthiazol-2-yl-2,5-diphenyltetrazolium bromide assay and assessment of lactate dehydrogenase leakage.

Descriptors:

• *DUST
• *PARTICLES
• *RESPIRATORY SYSTEM
• GEOGRAPHY
• IN VITRO ANALYSIS
• IN VIVO ANALYSIS
• LUNG
• RATS
• SAND
• TOXICITY

Subject Categories:

• Anatomy and Physiology
• Medicine and Medical Research
• Geology, Geochemistry and Mineralogy

Distribution Statement:

APPROVED FOR PUBLIC RELEASE